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: Vitamin D Binding Protein, Serum, Mass Concentration

Published: August 9, 2026Updated: August 17, 2026

: This test measures the amount of vitamin D binding protein in a serum sample. Vitamin D binding protein is a liver-made protein that carries vitamin D and its related metabolites through the bloodstream.

Quick summary

[": The test quantifies vitamin D binding protein in serum to help evaluate how vitamin D is transported and distributed in the body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
107221-4
Short code
Vit D binding protein SerPl-mCnc
Synonyms
Vit D binding protein SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What Is Vitamin D Binding Protein?

: Vitamin D binding protein is a protein produced mainly by the liver. Its primary job is to bind vitamin D and its metabolites and carry them through the blood, helping regulate how much free vitamin D is available to tissues.

: Why Measure It?

: Measuring this protein can help clinicians assess vitamin D transport and interpret vitamin D status, especially when vitamin D levels appear unexpectedly low or high or when a transport or binding problem is suspected.

: How the Test Is Done

: A blood sample is drawn from a vein, usually in the arm, and the serum is separated for analysis. The laboratory measures the mass concentration of the protein, meaning the amount present per volume of serum.

: What the Results Mean

: Results are reported as a concentration and are interpreted alongside other findings such as vitamin D metabolite levels, kidney and liver function, and the overall clinical picture. A single value is rarely meaningful on its own.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: Vitamin D Binding Protein

Frequently asked questions

: Does this test tell me whether I have enough vitamin D?
: Not directly. This test measures the carrier protein, not vitamin D itself. Vitamin D status is usually assessed with separate tests for vitamin D metabolites, and this protein result is interpreted together with those and other findings.
: Do I need to fast before this test?
: Fasting requirements vary by laboratory and by the clinician's orders. Follow the instructions provided by your healthcare provider or the testing laboratory.
: Can a low result mean I have a health problem?
: A low or high result can occur with several conditions, including liver or kidney disease and other states that affect protein production or loss, as well as inherited differences in the protein. Your provider will interpret the result in the context of your symptoms, history, and other tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy