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Vitamin K-dependent clotting factors (serum/plasma mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the levels of specific blood proteins involved in blood clotting, which rely on Vitamin K for proper function.

Quick summary

["Vitamin K factors help control bleeding by promoting blood clotting."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33403-7
Short code
VLCFA C26:0 SerPl-mCnc
Synonyms
VLCFA C26:0 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for blood clotting disorders, liver disease, or issues related to Vitamin K deficiency. It can also help monitor treatment for conditions like bleeding disorders or those requiring anticoagulant medications.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw blood. If you’re on anticoagulants, your provider may ask you to stop certain medications temporarily.

What the Test Results Mean

Results show the mass concentration of Vitamin K-dependent clotting factors (e.g., factors II, VII, IX, X). Abnormal levels may indicate bleeding risks, clotting disorders, or liver problems.

Common Conditions Linked to This Test

Low levels might suggest Vitamin K deficiency, liver disease, or conditions like hemophilia. High levels could be seen in rare cases of overproduction or certain genetic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Vitamin K Factors

Frequently asked questions

What causes abnormal Vitamin K factor levels?
Abnormal results could stem from liver disease, Vitamin K deficiency (e.g., due to poor diet, bowel disorders, or medications), or inherited clotting disorders. Anticoagulant medications (like warfarin) can also affect these levels.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will discuss them with you during your follow-up visit.
Can diet affect this test?
Yes, diets low in Vitamin K (e.g., very little leafy greens) may lower factor levels. Avoiding certain medications (like blood thinners) for a set period before testing is also important.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy