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Vitamin K-dependent clotting factors (Serum Protein Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the levels of specific proteins in your blood that help with blood clotting. These proteins depend on vitamin K for proper function.

Quick summary

["Understanding your blood clotting protein levels can help identify issues with blood clotting or bleeding risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54446-0
Short code
VLCFA C26:1 SerPl-mCnc
Synonyms
VLCFA C26:1 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test evaluates the mass concentration of vitamin K-dependent clotting factors in your serum. These factors include proteins like prothrombin, factors VII, IX, and X, which are essential for blood coagulation.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms of bleeding disorders, if you’re taking medications that affect blood clotting (like warfarin), or if you have conditions that can interfere with vitamin K metabolism.

Common Reasons for Testing

Conditions such as liver disease, vitamin K deficiency, or certain genetic disorders may require this test to assess how well your blood can clot properly.

Sample Collection and Preparation

Blood is drawn from a vein, usually in your arm, and sent to a lab for analysis. The serum portion (liquid after blood clots) is used for this test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Vitamin K Factors

Frequently asked questions

What does a low level of these factors mean?
A low level may mean you have a higher risk of bleeding, especially if you’re on blood-thinning medications or have conditions like liver disease or vitamin K deficiency.
What if my test results are normal?
Normal results suggest your blood clotting proteins are functioning as expected, but follow-up may still be needed if you have symptoms or risk factors for bleeding disorders.
How often should I get this test?
Your doctor will determine the frequency based on your medical history, current medications, and symptoms. Regular monitoring may be recommended if you have chronic conditions affecting clotting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy