Very-Low-Density Lipoprotein (VLDL) Fractions 1 and 2 Cholesterol, Serum/Plasma — Mass Concentration
Measures cholesterol in the VLDL-1 and VLDL-2 fractions, which are very-low-density lipoprotein particles that transport triglycerides in the blood.
["This specialized lipid test helps assess triglyceride-rich cholesterol particles that may contribute to cardiovascular risk."]
Key facts at a glance
- LOINC
- 49624-0
- Short code
- VLDL1+2c SerPl-mCnc
- Synonyms
- VLDL1+2c SerPl-mCnc
- Category
- lipid
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 100
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 83721
- SNOMED
- 113079007
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures the amount of cholesterol in two fractions of very-low-density lipoprotein (VLDL), called VLDL-1 and VLDL-2. VLDL particles carry triglycerides through the bloodstream and can eventually become other cholesterol-carrying particles.
Why might I need this test?
It may be ordered as part of an advanced evaluation of high triglycerides, an unusual cholesterol pattern, or an inherited lipid disorder. Results may be considered along with triglycerides, HDL cholesterol, LDL cholesterol, and overall cardiovascular risk.
How is the test performed?
A blood sample is collected, and the serum or plasma is analyzed to determine the mass concentration of cholesterol in the VLDL-1 and VLDL-2 fractions. Some laboratories may calculate or estimate these values from other lipid measurements.
How do I prepare for the test?
Fasting is not always required, but your clinician or laboratory may ask you to fast, especially when triglycerides are being evaluated. Follow the instructions provided with the test order and tell the laboratory if you recently ate.
Reference range
Optimal: <100 mg/dLN/A
Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated VLDL fraction cholesterol can be associated with high triglycerides, insulin resistance or diabetes, kidney disease, and inherited lipid disorders, and it may increase cardiovascular risk. Results should be interpreted with the rest of the lipid panel because VLDL particles exchange lipids with HDL and LDL. A low result is generally less clinically important, but it should still be reviewed with your clinician.
Short name
VLDL Fraction Cholesterol
Frequently asked questions
Is this the same as an LDL cholesterol test?
Do I need to fast before this test?
What can cause elevated VLDL fraction cholesterol?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy