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VLDL 3-4 Cholesterol, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures cholesterol in the VLDL 3-4 fraction, which contains triglyceride-rich remnant particles that can contribute to cardiovascular risk.

Quick summary

["This test measures cholesterol carried by VLDL remnant particles, which may help evaluate lipid-related cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47218-3
Short code
VLDL3+4c SerPl-mCnc
Synonyms
VLDL3+4c SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of cholesterol in a specific fraction of very low-density lipoprotein (VLDL) called VLDL 3-4. These particles are remnants that circulate after the liver releases triglycerides and may contribute to plaque buildup in the arteries.

Why might I need this test?

It may be ordered as part of an advanced evaluation of high cholesterol or triglycerides, especially when standard lipid results are unclear or when a inherited or secondary lipid disorder is suspected. It can also help assess cardiovascular risk associated with circulating remnant particles.

How is the test performed?

A blood sample is collected, and the serum or plasma is used to measure VLDL 3-4 cholesterol. Depending on the laboratory, this fraction may be obtained through specialized lipid separation or calculated from other lipid measurements.

How do I prepare for the test?

Follow your laboratory's preparation instructions. This measurement is often part of a broader lipid evaluation, so fasting may be requested when triglycerides or other cholesterol measurements are also being assessed.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

VLDL 3-4 cholesterol

Frequently asked questions

What is VLDL 3-4 cholesterol?
It is the cholesterol carried by a specific fraction of VLDL particles. These particles are lipid remnants that may promote cholesterol deposition in artery walls.
What does an elevated result mean?
It may suggest increased circulating remnant particles, which can be associated with cardiovascular risk and several metabolic, kidney, liver, or genetic conditions. The result should be interpreted with other lipid tests.
Do I need to fast before this test?
Fasting may be required if the test is ordered with triglycerides or as part of a broader lipid panel. Follow the specific instructions provided by your laboratory.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy