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Very-Low-Density Lipoprotein Cholesterol, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

VLDL cholesterol measures cholesterol carried by very-low-density lipoproteins in the blood. It is often calculated from a standard lipid panel.

Quick summary

["This test helps assess the amount of cholesterol carried in triglyceride-rich VLDL particles."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47219-1
Short code
VLDL5+6c SerPl-mCnc
Synonyms
VLDL5+6c SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

Very-low-density lipoprotein (VLDL) is a type of cholesterol-carrying particle in the blood. This test measures the concentration of cholesterol in VLDL, often as part of a lipid panel.

Why might I need this test?

VLDL cholesterol may be used to help assess cardiovascular risk, particularly when total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides are also evaluated.

How is the test performed?

A blood sample is collected and analyzed for lipids. In many laboratories, the VLDL cholesterol value is calculated from the triglyceride and cholesterol results rather than measured directly.

How do I prepare for the test?

Follow your clinician's instructions about fasting. Some lipid tests are more accurate after an overnight fast, while others may be performed without fasting. Continue medications as directed unless your clinician tells you otherwise.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated VLDL cholesterol can be associated with high triglyceride levels, obesity, diabetes, or an increased risk of cardiovascular disease. Low levels are generally less concerning, but results should be interpreted with the rest of the lipid panel and your medical history.

Short name

VLDL Cholesterol

Frequently asked questions

Is VLDL cholesterol the same as LDL cholesterol?
No. VLDL and LDL are different types of cholesterol-carrying particles. VLDL mainly transports triglycerides to the liver, while LDL carries cholesterol to tissues and is closely linked to cardiovascular risk.
Is this test calculated or measured directly?
It is commonly calculated from other lipid measurements, especially triglycerides and total cholesterol. The laboratory report should indicate whether the result was calculated.
Do I need to fast for this test?
Fasting may be requested, especially when triglycerides are being evaluated. If you are unsure, ask your clinician or laboratory before the blood draw.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy