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VLDL Cholesterol, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures very-low-density lipoprotein cholesterol in blood, helping assess triglyceride-rich lipids and cardiovascular risk.

Quick summary

["Higher VLDL cholesterol often accompanies high triglycerides and increased cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
66499-5
Short code
VLDLc beta SerPl-mCnc
Synonyms
VLDLc beta SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures the amount of cholesterol carried in very-low-density lipoprotein (VLDL) particles. VLDL is made mainly by the liver and helps transport triglycerides to body tissues.

Why might I need this test?

VLDL cholesterol may be included in a lipid panel or checked when triglycerides are elevated. It can help your clinician evaluate cholesterol levels and cardiovascular risk.

How is the test performed?

A blood sample is drawn and analyzed in a laboratory. Depending on the laboratory method, VLDL cholesterol may be measured directly or calculated from other cholesterol and triglyceride measurements.

How do I prepare for the test?

Follow your clinician's instructions about fasting, because eating can raise triglycerides and affect lipid results. If fasting is requested, it is commonly for 8 to 12 hours, and water is usually allowed.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

VLDL cholesterol

Frequently asked questions

Is VLDL cholesterol the same as LDL cholesterol?
No. VLDL and LDL are different classes of cholesterol-carrying particles. VLDL mainly carries triglycerides, while LDL primarily carries cholesterol to body tissues.
Does a high VLDL cholesterol result mean I have heart disease?
No. It is a risk marker and does not by itself diagnose heart disease. Your clinician will interpret it alongside other lipids, blood pressure, diabetes status, smoking, and overall cardiovascular risk.
Do I need to fast for this test?
Fasting may be required, especially when triglycerides are being evaluated or when the test is part of a complete lipid panel. Follow the specific instructions provided by your clinician or laboratory.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy