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VLDL Cholesterol, Serum/Plasma — Calculated, Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Estimates the amount of cholesterol carried by VLDL particles in the blood, usually calculated from results in a lipid panel.

Quick summary

["This test helps assess cholesterol distribution and triglyceride-related cardiovascular risk as part of a lipid evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13458-5
Short code
VLDLc SerPl Calc-mCnc
Synonyms
VLDLc SerPl Calc-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
calculated
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

VLDL cholesterol measures the cholesterol carried by very-low-density lipoprotein particles. It is usually calculated from other lipid panel results, especially triglycerides and HDL cholesterol, rather than measured directly.

Why might I need this test?

This test may be ordered to evaluate cholesterol levels, high triglycerides, and cardiovascular risk. It can also help guide lifestyle changes or treatment for abnormal lipid levels.

How is the test performed?

A blood sample is drawn from a vein and analyzed as part of a lipid panel. The laboratory then estimates VLDL cholesterol using the triglyceride, total cholesterol, and HDL cholesterol results.

How do I prepare for the test?

Follow your clinician's instructions about fasting. If fasting is required, it is commonly 8 to 12 hours, and water is usually allowed. Tell your clinician if you have recently changed medications or supplements.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Calculated VLDL Cholesterol

Frequently asked questions

Is VLDL cholesterol measured or calculated?
It is usually calculated from other results in a lipid panel rather than measured directly. Direct VLDL testing may be used in selected situations.
Do I need to fast for this test?
Fasting may be required, particularly when triglycerides are being evaluated. Ask your clinician whether you should fast and for how long before the blood draw.
Can a high VLDL cholesterol result be treated?
Yes. Treatment may include dietary changes, physical activity, weight management, and medication when appropriate. Your clinician will base recommendations on the complete lipid panel and your cardiovascular risk.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy