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VLDL Cholesterol, Serum/Plasma — Calculated, Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

A calculated blood test estimating cholesterol carried in very low-density lipoprotein particles, which transport triglyceride-rich lipids.

Quick summary

["VLDL cholesterol is usually calculated from other lipid results and is interpreted alongside LDL cholesterol, HDL cholesterol, and triglycerides."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
66126-4
Short code
VLDLc SerPl Calc-sCnc
Synonyms
VLDLc SerPl Calc-sCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
calculated
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

VLDL cholesterol measures the estimated amount of cholesterol in very low-density lipoprotein particles. These particles carry cholesterol and especially triglycerides through the bloodstream.

Why might I need this test?

This test may be included in a lipid panel to help assess cardiovascular risk. Your clinician may also use it when evaluating high triglycerides, cholesterol treatment, or overall lipid status.

How is the test performed?

A blood sample is taken from a vein. The laboratory usually calculates VLDL cholesterol from other results in the same sample, commonly total cholesterol, HDL cholesterol, and triglycerides, although calculation methods can vary.

How do I prepare for the test?

Follow your clinician's fasting instructions. For a lipid panel, fasting for at least 9 to 12 hours may be recommended, and water is generally the only permitted drink unless your clinician says otherwise.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

VLDL Cholesterol

Frequently asked questions

Is VLDL cholesterol measured directly?
Usually, no. It is commonly calculated from other lipid measurements in the same blood sample, so the laboratory's calculation method may vary.
Why does my VLDL cholesterol result change?
It can change with weight, diet, physical activity, diabetes, medications, and other conditions that affect cholesterol or triglycerides. Changes in the other lipid values used in the calculation can also affect the result.
Do I need to fast before this test?
It depends on your clinician's instructions and whether the test is part of a broader lipid panel. If fasting is requested, it commonly lasts at least 9 to 12 hours, with water usually allowed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy