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Prostate-Specific Antigen (PSA) Volume Derived from Urine (24-Hour Collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of prostate-specific antigen (PSA), a protein produced by the prostate gland, collected in urine over 24 hours. It helps assess prostate health and detect potential issues like benign prostatic hyperplasia (BPH) or prostate cancer.

Quick summary

["Assessing prostate function and potential abnormalities through urine PSA volume over a full day."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
15315-5
Short code
Volume Prostate US.derived.PLN
Synonyms
Volume Prostate US.derived.PLN
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-derived-pln
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Used

Doctors may order this test if you have symptoms like frequent urination, difficulty urinating, or if you’re at higher risk for prostate conditions. It can also be part of monitoring for prostate cancer or other prostate-related disorders.

How the Test Works

You’ll collect all urine for a full 24-hour period in a special container. The urine is then sent to the lab for analysis to determine the total PSA volume.

Sample Collection and Preparation

Wash your hands before collecting urine. Use the provided container and empty your bladder completely at the start and end of the 24-hour period. Store urine at room temperature if not processed immediately.

What to Expect Before the Test

No special preparation is needed, but avoid using medications that may affect PSA levels (like finasteride or dutasteride) unless your doctor advises otherwise. Inform your doctor about all medications you’re taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

24-Hour Urine PSA Volume

Frequently asked questions

This test helps evaluate prostate health by measuring PSA excretion in urine, which can indicate prostate enlargement, inflammation, or cancer. Elevated levels may signal underlying issues that require further investigation.
This test is not a standalone diagnostic tool for prostate cancer but can be part of a broader evaluation when symptoms or risk factors are present.
How does urine PSA volume differ from blood PSA tests?
Urine PSA volume measures the total PSA excreted in urine over 24 hours, while blood PSA tests measure PSA levels in the blood. Both can be useful but are often used together for a more comprehensive assessment.
Can diet or medications affect urine PSA volume?
Certain foods, supplements, or medications (like finasteride) may influence PSA levels. Your doctor will guide you on any necessary adjustments before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy