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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum, which includes important substances like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Your blood protein levels can signal health issues like dehydration, liver or kidney problems, or nutritional deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
15313-0
Short code
Volume Testis-R US.derived.ROT
Synonyms
Volume Testis-R US.derived.ROT
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-derived-rot
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions affecting your liver, kidneys, immune system, or overall hydration. It’s also used in diagnosing malnutrition, certain cancers, or monitoring chronic diseases like kidney disease or inflammatory disorders.

What Does the Test Involve?

A blood sample is drawn from a vein in your arm. The blood is then separated into serum (the liquid part after clotting) and analyzed in a lab to measure protein concentration. Results are typically available within 24–48 hours.

What Are Common Results?

Results are reported in grams per deciliter (g/dL). While reference ranges vary by lab, lower levels may indicate malnutrition or organ dysfunction, while higher levels could suggest conditions like multiple myeloma or severe dehydration.

Factors That Can Affect Results

Eating a high-protein meal before testing, certain medications (e.g., steroids), or conditions like kidney disease or liver disease can influence protein levels. Recent blood loss or dehydration may also impact results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What Does a Low Total Protein Level Mean?
Low protein levels may signal malnutrition, liver or kidney disease, or chronic inflammation. For example, low albumin (a key protein) can cause swelling (edema) or poor wound healing. Always discuss results with your healthcare provider.
What Does a High Total Protein Level Mean?
High protein levels can occur with conditions like multiple myeloma (a blood cancer), severe dehydration, or certain infections. High globulin levels may indicate chronic inflammation or autoimmune diseases. Your doctor will interpret results in context with your symptoms.
How Often Should This Test Be Done?
This test is often part of routine blood work or monitoring for chronic conditions. Frequency depends on your health needs—your doctor will determine if repeat testing is needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy