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Vitamin K-dependent clotting factors (Prothrombin Complex Concentrate, PCC) Activity

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of vitamin K-dependent clotting factors in your blood, which are essential for blood clotting. It helps assess how well your blood can clot when needed.

Quick summary

["This test helps evaluate bleeding risks and effectiveness of treatments for clotting disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93371-3
Short code
vWF Cp Act PPP Chro-cCnc
Synonyms
vWF Cp Act PPP Chro-cCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
chromo
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test checks the combined activity of several key clotting proteins (such as prothrombin, factors VII, IX, and X) that rely on vitamin K for proper function. These factors work together to help your blood form clots when injured.

Why It’s Ordered

Your healthcare provider may order this test if you have bleeding problems, take blood thinners, or have conditions like liver disease, vitamin K deficiency, or inherited clotting disorders.

Preparation and Sample Collection

No special preparation is needed, but you may be asked to stop certain medications (like blood thinners) before testing. Blood is drawn from a vein in your arm.

What to Expect After the Test

You may feel slight discomfort during the blood draw, but it usually resolves quickly. Follow-up care depends on your treatment plan, such as monitoring or adjustments to medication.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

PCC Activity Test

Frequently asked questions

Why might my test results be different from what I expected?
Results can vary based on recent blood loss, medications (like vitamin K supplements), or liver function. Always discuss your results with your provider for personalized interpretation.
How long will it take to get my results?
Results are typically available within 24 hours, but timing depends on lab processing and your healthcare provider’s workflow.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise, as this test does not require fasting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy