Protein Electrophoresis with Plasma Protein Fractionation (Bromocresol Green/Dye Binding)
This test measures the distribution of different protein types in your plasma, often used to identify abnormalities in protein levels that may suggest conditions like kidney disease, liver issues, or certain blood disorders.
["Assessing protein balance in your blood can help detect underlying health problems."]
Key facts at a glance
- LOINC
- 24376-6
- Short code
- vWF multimers PPP IA-aCnc
- Synonyms
- vWF multimers PPP IA-aCnc
- Category
- chemistry
- Sample
- plasma
- Container
- Lavender-top (EDTA) or Green-top (Heparin)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test uses a technique called electrophoresis to separate plasma proteins based on size and charge. Specific dyes (bromocresol green) bind to different protein groups, allowing for qualitative analysis of protein fractions such as albumin, globulins, and other plasma proteins. This helps identify shifts in protein composition that may indicate conditions like hypoalbuminemia, dysproteinemias, or immune system dysfunctions.
Why It’s Done
Your healthcare provider may order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or if they suspect conditions like multiple myeloma, amyloidosis, or chronic kidney disease. It’s also used as part of routine monitoring for certain diseases.
Sample Collection and Preparation
A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate plasma, which is then analyzed. No special preparation is needed, but fasting may be advised depending on your specific test order.
Interpretation and Results
Results are qualitative and describe the relative amounts of different protein fractions. Abnormal patterns may show up as shifts in bands or unusual densities, which can guide further testing or treatment planning.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal protein electrophoresis can reveal conditions affecting protein synthesis, storage, or breakdown. For example, high levels of certain globulins may indicate immune disorders, while low albumin levels could signal liver or kidney disease. This test is critical for diagnosing and managing conditions that alter protein metabolism, such as monoclonal gammopathies or systemic amyloidosis.
Short name
Plasma Protein Electrophoresis
Frequently asked questions
What does a 'qualitative' result mean?
How long does it take to get results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy