Protein Electrophoresis with Multimer Analysis of Plasma Proteins (Screening)

What This Test Measures

Protein electrophoresis separates proteins in your blood plasma by size and charge, revealing patterns that may indicate issues with protein fragments (multimers). Multimers are abnormal protein clusters that can form due to conditions like liver disease, clotting disorders, or certain genetic disorders. This test specifically looks at plasma proteins, which include factors involved in clotting, immune response, and transport of substances in your blood.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms like easy bruising, excessive bleeding, fatigue, or signs of liver disease. It may also be used as part of a broader evaluation for conditions affecting protein synthesis or breakdown, such as hereditary angioedema or certain clotting disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate plasma, which is then analyzed for protein multimer patterns. This test does not require fasting and is generally performed in a clinical laboratory.

Common Conditions Monitored

This test is particularly useful for identifying hereditary angioedema, a rare genetic disorder causing swelling due to abnormal C4 protein fragments. It may also help evaluate other conditions affecting protein structure, such as certain liver diseases or acquired protein abnormalities.