Total Protein in Cerebrospinal Fluid (CSF)
This test measures the total amount of protein found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Proteins in CSF can help identify issues like inflammation, infection, or blood leakage into the brain.
["Protein levels in CSF may signal underlying neurological conditions."]
Key facts at a glance
- LOINC
- 93786-2
- Short code
- VZV Ab.IgM+total CSF Ql
- Synonyms
- VZV Ab.IgM+total CSF Ql
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if they suspect conditions such as meningitis, encephalitis, multiple sclerosis, or other brain or spinal cord disorders. It can also help diagnose or monitor conditions like brain tumors, bleeding, or certain autoimmune diseases.
What to Expect Before the Test
No special preparation is needed. You’ll have a small needle inserted into your back to collect a small amount of CSF, usually done in a hospital or clinic setting. You may feel mild discomfort, but it’s generally quick and well-tolerated.
What the Results Mean
Protein levels in CSF can vary widely depending on health status. High levels might suggest inflammation, infection, or blood in the CSF, while normal levels help rule out certain conditions. Your doctor will interpret results in the context of your symptoms and medical history.
Possible Risks and Side Effects
The most common side effect is a small bruise or soreness at the injection site. Rarely, there may be mild headaches or dizziness. Serious complications are uncommon but could include infection or bleeding at the site.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated protein levels in CSF often point to conditions like meningitis, Guillain-Barré syndrome, or demyelinating diseases. Low protein levels may indicate conditions such as cerebral edema or certain genetic disorders. Your doctor will guide you on next steps, which could include further testing, treatment adjustments, or monitoring.
Short name
CSF Total Protein
Frequently asked questions
What causes protein levels in CSF to be higher than normal?
How often should I expect to have this test repeated?
Can lifestyle changes affect CSF protein levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy