Skip to content

Total Protein in Serum (Electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulins. Proteins are essential for maintaining fluid balance, transporting nutrients, and supporting immune function.

Quick summary

["Your protein levels help assess overall health, hydration, and potential nutrient deficiencies or liver/kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43978-6
Short code
VZV Ab Ser Ql IA
Synonyms
VZV Ab Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters in Your Health

Protein is a critical component of your blood and body tissues. Low levels may indicate conditions like malnutrition, kidney disease, or liver problems, while high levels could suggest dehydration, inflammation, or certain cancers. This test helps doctors monitor conditions like chronic kidney disease, liver disorders, or immune system issues.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw a blood sample. If you’re on blood thinners or have a history of bleeding issues, let your provider know.

Common Conditions Monitored

Your protein levels are often checked if you have symptoms like unexplained weight loss, swelling, fatigue, or signs of organ dysfunction. Doctors may also order this test as part of routine check-ups or to evaluate chronic illnesses like kidney disease or autoimmune disorders.

What Your Results Mean

Results are usually reported as a total protein value (e.g., grams per deciliter). While reference ranges vary by lab, very low or very high values may prompt further testing to identify underlying causes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: How Protein Levels Impact Health

Short name

Total Serum Protein

Frequently asked questions

What causes low protein levels?
Low protein levels can result from conditions like malnutrition, kidney disease (which filters proteins), liver disease (where proteins aren’t made properly), or severe infections. Chronic conditions like inflammatory bowel disease or certain cancers may also lead to protein loss.
What causes high protein levels?
High protein levels can occur due to dehydration (your body concentrates proteins), certain cancers (like multiple myeloma), or severe infections. Rarely, high globulin levels may signal autoimmune diseases or chronic infections.
How often should this test be repeated?
Your doctor will determine how often to retest based on your symptoms, medical history, and test results. If your levels are abnormal, follow-up may include additional tests or treatments to address the underlying cause.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy