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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum, which helps assess overall protein levels and kidney function.

Quick summary

["Total protein helps evaluate protein balance and kidney health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5881-8
Short code
VZV Ag Skin Ql IF
Synonyms
VZV Ag Skin Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like malnutrition, kidney disease, liver problems, or certain infections. It can also help monitor long-term conditions like kidney disease or heart failure.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your provider specifies it, but this is not always required. Bring any medications you’re taking to your appointment.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm. You may feel a brief pinch or slight discomfort, but it usually doesn’t last long. The blood sample is then sent to a lab for analysis.

What Do Results Mean?

Results are used to compare against general reference ranges for healthy adults. Low protein levels may indicate malnutrition, kidney disease, or liver disorders, while high levels could suggest dehydration, inflammation, or certain medical conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What are the normal reference ranges for this test?
Normal reference ranges vary by lab and demographic factors (e.g., age, sex). Your results will be interpreted in relation to your specific baseline and any known health conditions. Always discuss your results with your healthcare provider.
How often should I get this test?
Your provider will determine how often you need this test based on your health status, symptoms, or ongoing conditions. Regular monitoring may be recommended if you have kidney disease, liver issues, or other chronic conditions.
Can diet or medications affect this test?
Yes, certain foods (like high-protein diets) and medications (e.g., steroids, some antibiotics) can influence protein levels. If you’re on medication or have dietary restrictions, let your provider know to avoid unexpected results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy