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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and compares albumin (the protein that helps maintain fluid balance) to globulins (proteins involved in immunity and clotting).

Quick summary

["Understanding your protein balance can help identify issues like infections, kidney problems, or liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17764-2
Short code
VZV IgG CSF-aCnc
Synonyms
VZV IgG CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

Total protein and albumin-globulin ratios are important because they reflect how well your body produces and maintains proteins. Low albumin may signal fluid retention or malnutrition, while abnormal globulin levels could hint at immune disorders or chronic inflammation.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours if your blood is drawn early in the morning. Wear a loose shirt for easy access.

What the Results Mean

Your results will show two key numbers: total protein (sum of albumin and globulins) and the albumin-to-globulin ratio. A higher ratio may suggest inflammation or infection, while a lower ratio could point to liver or kidney issues.

Common Conditions Linked to These Results

High protein levels might occur with dehydration or severe burns, while low levels can signal liver disease, kidney failure, or malnutrition. Globulin abnormalities often appear in autoimmune diseases or chronic infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: This test helps diagnose or monitor conditions like chronic inflammation, infections, liver disease, or kidney disorders by assessing protein production and immune function. It’s sometimes used alongside other blood tests to refine diagnoses.

Short name

Protein & Globulin Ratio

Frequently asked questions

What does a high total protein level mean?
A high total protein level may indicate dehydration, severe burns, or conditions that cause excessive protein production (e.g., multiple myeloma). Your doctor will consider your symptoms and other test results to determine the cause.
Why might my albumin-to-globulin ratio be low?
A low albumin-to-globulin ratio often suggests liver disease (reducing albumin production) or kidney problems (affecting protein filtering). Chronic infections or malnutrition can also contribute. Further testing may be needed to identify the exact issue.
Can diet affect these test results?
Yes, diet can influence protein levels. High-protein diets may temporarily raise total protein, while low-protein diets could lower it. Your doctor may recommend dietary adjustments if protein imbalances are suspected, especially if related to kidney or liver health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy