Serum or plasma concentration of total bilirubin

What is bilirubin and its role in the body?

Bilirubin is a byproduct of hemoglobin, the protein in red blood cells that carries oxygen. When old red blood cells are broken down in the spleen and liver, bilirubin is released. Normally, your liver processes bilirubin into a form that can be excreted in bile, which travels to your intestines. Too much bilirubin can cause jaundice, a condition where your skin and eyes turn yellow.

Why might my bilirubin levels be checked?

Your doctor may order a bilirubin test if you have symptoms like yellowing of the skin or eyes, unexplained fatigue, abdominal pain, or if they suspect liver disease, hemolytic anemia (a condition where red blood cells are destroyed too quickly), or bile duct blockage.

How is the bilirubin test performed?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure the total bilirubin concentration. The test can be done on serum (liquid part of blood after clotting) or plasma (liquid part of blood without clotting).

What do bilirubin levels tell us?

Low bilirubin levels are less common and may not cause symptoms. However, very low levels can sometimes be associated with certain genetic conditions or nutritional deficiencies.