Total Protein with Albumin-to-Globulin Ratio (Serum)
This test measures your blood’s total protein levels and compares albumin to globulin, two key protein groups that help maintain fluid balance and support immune function.
["Helps assess protein health and potential fluid imbalances in your blood."]
Key facts at a glance
- LOINC
- 22602-7
- Short code
- VZV IgG Titr Ser
- Synonyms
- VZV IgG Titr Ser
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 8
- Ref high
- 61
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82977
- SNOMED
- 3110003
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does Total Protein Measure?
Total protein includes albumin and globulin, which are produced by your liver and immune system, respectively. Albumin helps keep fluids in your bloodstream, while globulins assist with immune responses and blood clotting. Together, they reflect overall protein health.
Why Is the Albumin-to-Globulin Ratio Important?
The ratio compares albumin (a protein that helps prevent fluid leakage) to globulin (proteins involved in immunity and clotting). A higher albumin-to-globulin ratio often suggests healthy protein balance, while an imbalance may indicate conditions like liver disease, malnutrition, or chronic inflammation.
How Is This Test Performed?
A small blood sample is drawn from your arm, and the serum (liquid part after clotting) is analyzed to measure total protein and the albumin-to-globulin ratio using standard laboratory techniques.
When Might You Need This Test?
Your doctor may order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or signs of liver/kidney issues. It’s also used in routine health checks or to monitor chronic conditions.
Reference range
Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Total Protein & AG Ratio
Frequently asked questions
What causes low total protein levels?
How long does it take to get results?
Can diet affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy