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Serum or plasma concentration of **homocysteine** (substance concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of homocysteine, a type of amino acid (protein-building block) in your blood. It helps assess risks for certain health conditions.

Quick summary

Homocysteine levels can indicate potential heart disease or nerve damage risks.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
28170-9
Short code
WANTTODIEATHOME
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
reported-living-hiv
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Done

Your doctor may order this test if you have symptoms of nerve damage (neuropathy), heart disease risk factors, or if you’re being evaluated for conditions like vascular disease, kidney problems, or genetic disorders affecting folate and vitamin B12 levels. It may also be checked during pregnancy to monitor fetal development risks.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on folate or vitamin B12 supplements, let your doctor know—it may affect results.

What the Results Mean

High levels may suggest risks for blood vessel damage, nerve issues, or certain genetic conditions. Low levels could indicate deficiencies in folate or vitamin B12. Your doctor will interpret results in the context of your overall health.

Common Conditions Linked to Homocysteine Levels

Elevated homocysteine is often linked to cardiovascular disease (like heart attacks or strokes), peripheral neuropathy (nerve damage in hands/feet), and kidney disease. It may also play a role in pregnancy complications or cognitive decline.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Homocysteine as a Marker

Short name

Homocysteine Level

Frequently asked questions

What causes elevated homocysteine levels in my blood?
Elevated homocysteine can result from genetic factors, kidney disease, deficiencies in folate, vitamin B12, or vitamin D, heavy alcohol use, or certain medications (like some diuretics or chemotherapy drugs). Lifestyle factors like smoking or poor diet may also contribute.
How often should I get this test?
Your doctor will determine frequency based on your health status. For example, people with kidney disease or a family history of vascular disorders may need it more often. Pregnant women may be tested once during pregnancy.
Can I lower my homocysteine levels naturally?
Yes! Dietary changes (more leafy greens, nuts, fish) and supplements (folate, vitamin B6, B12) under medical supervision can help. Exercise, quitting smoking, and managing stress also support healthy levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy