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Serum Anti-Cardiolipin Antibody (IgG) with Immunoassay

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of antibodies in your blood that target cardiolipin, a fatty substance found in cell membranes. These antibodies may be linked to certain autoimmune conditions or blood clotting issues.

Quick summary

["This test helps assess potential autoimmune or clotting disorders by detecting abnormal antibody responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
88182-1
Short code
W bancr+B malayi IgG1 Ser Ql IA
Synonyms
W bancr+B malayi IgG1 Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test measures the level of antibodies in your blood. Antibodies are proteins your immune system makes to help fight infections, so this test shows whether your body has responded to a specific germ.

Your blood sample will be tested for IgG antibodies that bind to cardiolipin, a phospholipid commonly found in cell membranes. This is done using an immunoassay method, which detects the presence and concentration of these antibodies in your serum.

Your doctor may recommend this test if you were exposed to an infection, if you have symptoms that suggest a recent or past illness, or if they want to see whether your immune system has built a protective response.

Doctors may order this test if you have symptoms like joint pain, unexplained fatigue, or a history of blood clots, or if you have conditions like lupus or other autoimmune diseases. It can also be part of screening for antiphospholipid syndrome.

A positive result means antibodies were detected in your blood sample. This usually shows that you were exposed to the infection at some point, either recently or in the past, and your immune system responded by making antibodies.

A positive result indicates the presence of elevated IgG anti-cardiolipin antibodies, which may suggest an autoimmune response or increased risk of blood clots. However, this alone does not diagnose a specific condition and may require further evaluation.

Common symptoms to watch for include fever, tiredness, cough, body aches, and headache. If you develop these symptoms, especially after a known exposure to an infection, contact your doctor to ask whether this testing is right for you.

Symptoms that might prompt this test include recurrent blood clots, unexplained miscarriages, chronic fatigue, or symptoms of autoimmune diseases such as joint pain, rashes, or neurological issues. Always discuss symptoms with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Anti-Cardiolipin Antibodies and Health Conditions

Short name

IgG Anti-Cardiolipin Antibody (ACA IgG)

Frequently asked questions

What are the possible causes of abnormal results?
How is this antibody test different from other antibody tests that doctors use to check for a past infection or an immune response?
Unlike some other antibody tests (e.g., ANA for antinuclear antibodies), this test specifically targets cardiolipin, a phospholipid involved in blood clotting. It is often used in combination with other tests to diagnose conditions like antiphospholipid syndrome.
Can lifestyle changes such as diet, exercise, or sleep habits affect the result of this antibody test in any way?
While lifestyle factors like diet, stress, or certain medications may influence immune responses, they typically do not directly alter the measured antibody levels in this test. However, chronic conditions or medications that affect the immune system could influence results.
Ideally, this test should be performed after consulting with your healthcare provider, who will consider your symptoms, medical history, and other test results. Symptoms may vary, but timing is best discussed with your doctor to ensure accurate diagnosis and treatment planning.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy