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Serum or Plasma Total Lipoprotein(a) Concentration (Lp(a))

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of lipoprotein(a) in your blood, a type of cholesterol-related protein that may increase your risk of heart disease.

Quick summary

["Lipoprotein(a) levels help assess cardiovascular risk and guide potential preventive care."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51770-6
Short code
WBC #/area Stl HPF
Synonyms
WBC #/area Stl HPF
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Ref low
10
Ref high
40
Critical range
2 N/A – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light-hpf
CPT
84484
SNOMED
302774002
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

What Is Lipoprotein(a)?

Lipoprotein(a), or Lp(a), is a unique lipoprotein particle that combines cholesterol with a protein called apolipoprotein(a). Unlike regular cholesterol, Lp(a) is strongly linked to higher risks of heart attacks, strokes, and blood vessel blockages. It persists at higher levels in some people’s blood for life, making it a key marker for long-term cardiovascular health.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma for testing. The test uses a specialized immunoassay method to detect and quantify Lp(a) levels precisely.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a family history of heart disease, high cholesterol, or other risk factors. It may also be recommended for people with known cardiovascular conditions to monitor progression or guide treatment decisions.

What Do Results Mean?

Results provide a numerical measurement of Lp(a) concentration in your blood. While there are no universally accepted reference ranges for Lp(a), higher levels are associated with increased cardiovascular risk. Your results will be interpreted in the context of your overall health and medical history.

Reference range

Adult: 10-40 U/LN/A

Specimen: stool

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Lp(a) Level

Frequently asked questions

Why do some people have higher Lp(a) levels?
Lp(a) levels are influenced by genetics—some people are born with naturally higher concentrations. While lifestyle factors like diet and exercise may have a minor impact, they are less effective at lowering Lp(a) than other cholesterol types. If your levels are elevated, your doctor may discuss strategies to manage cardiovascular risk, such as medications or lifestyle changes.
Can Lp(a) levels change over time?
Unlike some cholesterol measures, Lp(a) levels are relatively stable and do not change significantly with diet or exercise. However, certain medications (like certain cholesterol-lowering drugs) may have a modest effect, so follow-up testing may be recommended if you’re on long-term treatment.
Is this test covered by insurance?
Some insurance plans may cover this test if it’s ordered for clinical reasons, such as evaluating cardiovascular risk. Check with your insurance provider or healthcare team to confirm coverage details before scheduling the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy