Whole Blood Cell Disintegration Profile (Cerebrospinal Fluid)
This test evaluates the breakdown of cells in cerebrospinal fluid (CSF) to help identify potential abnormalities in the brain’s protective fluid.
["Assessing CSF cell integrity may help diagnose neurological conditions."]
Key facts at a glance
- LOINC
- 55599-5
- Short code
- WBC.disintegrated NFr CSF Manual
- Synonyms
- WBC.disintegrated NFr CSF Manual
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 4.5
- Ref high
- 11
- Critical range
- 2 N/A – 30 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- manual-count
- CPT
- 85004
- SNOMED
- 900000000000003002
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
This test measures the level of specific substances in your body, such as hormones, proteins, enzymes, or other markers that your doctor relies on to see how well certain organs and body systems are working. By looking closely at these measured values, your care team can gain a clearer picture of what is happening inside your body.
The test analyzes components released when cells in CSF disintegrate. This can include fragments of red blood cells, white blood cells, or other cellular debris, which may indicate bleeding, inflammation, or infection in the central nervous system.
Your doctor may order this test if you have symptoms that need a closer look, if you are living with a condition that requires regular monitoring, or as part of a routine checkup to screen for early signs of illness. The results can help confirm or rule out a diagnosis and guide decisions about your treatment plan.
Your doctor may order this test if you have symptoms like headaches, neurological issues, or signs of bleeding/infection in the brain, such as seizures, confusion, or vision changes. It’s also used in diagnosing conditions like meningitis, subarachnoid hemorrhage, or other CSF-related disorders.
How the sample is collected depends on the type of test your doctor has ordered, but it is most often done by drawing a small amount of blood from a vein in your arm or by asking you to provide a urine specimen. A trained healthcare professional will handle the collection, and the process is usually quick, causing little more than a brief sting or pinch.
A small amount of CSF is collected via a lumbar puncture (spinal tap) using a needle inserted into your lower back. The fluid is then sent to the lab for analysis.
Your results are compared with established reference ranges to see whether your values fall within what is considered normal for healthy adults. A value that is higher or lower than expected can point to an underlying condition, but numbers alone never tell the whole story, so only your doctor can interpret the result in the context of your symptoms, medical history, and overall health.
Results are qualitative (descriptive) rather than numerical, focusing on patterns of cell breakdown. High levels of certain debris may suggest bleeding, infection, or other underlying issues. Your doctor will interpret results in the context of your symptoms and medical history.
Reference range
Adult: 4.5-11.0 x 10^9/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
None
Frequently asked questions
This test helps detect conditions affecting CSF integrity, such as traumatic injury, infections (e.g., bacterial or viral meningitis), or bleeding into the spinal canal. It’s particularly useful for ruling out serious neurological emergencies.
Results are typically available within 24 to 48 hours, depending on lab processing times. Your doctor will discuss findings with you during your follow-up visit.
If you experience severe or worsening headaches before your lumbar puncture, inform your doctor immediately. They may adjust your care plan, such as postponing the test or using alternative diagnostic methods.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy