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White Blood Cell Differential with Autohematology (Auto-WBC Differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the types and proportions of white blood cells in your blood, using automated technology to analyze your sample.

Quick summary

["It helps identify imbalances that may signal infections, inflammation, or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
82587-7
Short code
WBC # Mar Auto
Synonyms
WBC # Mar Auto
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.5
Ref high
11
Critical range
2 N/A – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
CPT
85004
SNOMED
900000000000003002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to diagnose or monitor conditions like infections (e.g., bacterial or viral), autoimmune diseases, or blood disorders. It can also help track responses to treatments or check for signs of chronic conditions.

What to Expect Before the Test

No special preparation is needed. You’ll typically provide a simple blood draw, usually from a vein in your arm. The test uses an automated machine to count and classify white blood cells.

What the Results Mean

The results show the percentage of different white blood cell types (e.g., neutrophils, lymphocytes, eosinophils). Abnormal levels may indicate infections, allergies, or other health issues. Your doctor will interpret these results in the context of your overall health.

Common Conditions Monitored

This test is useful for diagnosing infections (like pneumonia or urinary tract infections), assessing immune responses, or evaluating conditions like leukemia, lymphoma, or chronic inflammatory diseases.

Reference range

Adult: 4.5-11.0 x 10^9/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

WBC Differential (Auto)

Frequently asked questions

What does an abnormal white blood cell differential mean?
An abnormal differential means the proportions of white blood cells don’t match what’s expected. This could signal infections, inflammation, or other health problems. Your doctor will discuss the results with you and may recommend further testing.
How often should I get this test?
The frequency depends on your health needs. Your doctor may order it periodically if you have chronic conditions, are recovering from an illness, or are undergoing treatment for a blood-related disorder.
Does this test hurt?
The blood draw itself may cause a slight pinch, but most people find it brief and manageable. The automated analysis afterward is painless and quick.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy