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Fetal hemoglobin concentration in maternal serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of fetal hemoglobin (HbF) in your blood, which is a type of hemoglobin found in fetal red blood cells. It helps assess fetal development and certain blood disorders.

Quick summary

["HbF levels can indicate fetal health and potential genetic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61182-2
Short code
WBC nRBC cor # Bld Fetus
Synonyms
WBC nRBC cor # Bld Fetus
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.5
Ref high
11
Critical range
2 N/A – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85004
SNOMED
900000000000003002
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you are pregnant or planning pregnancy and have risk factors for conditions like sickle cell disease, thalassemia, or other hemoglobinopathies. It can also be used to monitor fetal development during pregnancy.

What Does the Test Involve?

A blood sample is taken from your arm. The blood is processed to separate serum or plasma, which is then analyzed to measure HbF concentration using a specialized laboratory method.

What Are the Results Used For?

Results help identify if there are genetic risks related to hemoglobin disorders in your baby. They may also guide prenatal care decisions, such as genetic counseling or further testing.

What Should You Expect Before or After the Test?

No special preparation is needed. You may feel slight discomfort from the needle, but it usually goes away quickly. If you have any concerns about blood draws, let your provider know.

Reference range

Adult: 4.5-11.0 x 10^9/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HbF Maternal Serum/Plasma

Frequently asked questions

Why might my healthcare provider recommend this test during pregnancy?
Your provider may recommend it if you have a family history of hemoglobin disorders, certain ethnic backgrounds associated with higher risk, or if you are experiencing symptoms that could indicate a blood-related condition in your pregnancy.
What does an abnormal HbF result mean?
An abnormal result may indicate an increased risk for genetic blood disorders in your baby. This does not necessarily mean your baby has a problem, but it may lead to additional testing or genetic counseling to assess risks.
Can I eat or drink before this test?
You can eat and drink normally before this test, as no special preparation is required.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy