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White Blood Cell Differential (Autoimmune Hemolytic Anemia Screening) - Serum Autoantibody Test

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies in your blood that may attack your own red blood cells, which can cause a condition called autoimmune hemolytic anemia (AHA).

Quick summary

["This screening helps identify potential autoimmune reactions that might affect blood cell function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
809-4
Short code
WBC # Prt Auto
Synonyms
WBC # Prt Auto
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.5
Ref high
11
Critical range
2 N/A – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
CPT
85004
SNOMED
900000000000003002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, pale skin, or unusual bruising, or if you have a history of autoimmune diseases. It can also be part of a general blood workup to monitor certain conditions.

What to Expect Before the Test

No special preparation is needed. You’ll typically have a blood draw from a vein in your arm. If you’re on blood-thinning medications, let your provider know before the test.

What the Test Measures

This test detects specific antibodies in your serum that target red blood cells. These antibodies can be part of an autoimmune response, where your immune system mistakenly attacks healthy cells.

How the Results Are Interpreted

Results are reviewed by a healthcare provider to determine if antibodies are present. Elevated levels may suggest an autoimmune condition requiring further evaluation, such as additional blood tests or a consultation with a specialist.

Reference range

Adult: 4.5-11.0 x 10^9/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results may indicate autoimmune hemolytic anemia or other autoimmune disorders. Early detection can help guide treatment options, such as adjusting medications or monitoring closely. This test is often used as part of a broader diagnostic workup for unexplained anemia or immune-related symptoms.

Short name

Autoimmune Hemolytic Anemia (AHA) Autoantibody Screen (Serum)

Frequently asked questions

What does a positive result mean?
A positive result means your blood test detected antibodies that may attack your red blood cells. This could suggest an autoimmune condition, but further testing is needed to confirm the diagnosis and determine the best course of action.
Can lifestyle changes help if this test is positive?
While lifestyle changes like managing stress, eating a balanced diet, and avoiding known triggers (like certain medications) may support overall health, they are not a direct treatment for autoimmune conditions. Always follow your healthcare provider’s advice.
How often should I get this test?
Your provider will determine how often you need retesting based on your symptoms, medical history, and treatment plan. Regular follow-ups may be recommended if you have an ongoing condition or are on long-term treatment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy