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White Blood Cell Count (Serum/Plasma Substance Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the concentration of white blood cells in a blood sample, often performed to assess immune function or detect infections.

Quick summary

["White blood cells help fight infections and protect your body from illness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26469-7
Short code
WBC # Snv
Synonyms
WBC # Snv
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Ref low
4.5
Ref high
11
Critical range
2 N/A – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85004
SNOMED
900000000000003002
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Might You Need This Test?

Your doctor may order this test to check for signs of infection, inflammation, immune disorders, or other health conditions affecting your white blood cell levels. It can also be used during cancer treatments or to monitor recovery from surgery.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves drawing blood from a vein, but this is less common for this specific test. Avoid strenuous activity or medications that could affect results.

How the Test Is Performed

A healthcare provider will take a blood sample from a vein in your arm using a small needle. The blood is then sent to a lab for analysis. The test measures the total number of white blood cells in your serum or plasma.

What the Results Mean

Results are typically reported as a count of white blood cells per microliter (cells/µL). While reference ranges vary by lab, abnormal results may indicate low (leukopenia) or high (leukocytosis) white blood cell counts, which can signal infections, autoimmune diseases, or other health concerns.

Reference range

Adult: 4.5-11.0 x 10^9/LN/A

Specimen: fluid

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

WBC Count (Serum/Plasma)

Frequently asked questions

What Are Common Causes of Abnormal Results?
Low white blood cell counts (leukopenia) may be caused by infections, certain medications, autoimmune diseases, or conditions like aplastic anemia. High counts (leukocytosis) can result from infections, stress, inflammation, or certain cancers. Your doctor will consider your medical history and symptoms to interpret results accurately.
How Often Should I Get This Test?
The frequency depends on your health needs. Your doctor may recommend this test periodically if you have chronic conditions like cancer, HIV, or autoimmune disorders, or if you’re undergoing treatment that affects your immune system.
Can I Eat or Drink Before This Test?
No specific dietary restrictions apply to this test itself, but if it’s part of a broader blood workup (e.g., fasting tests), follow your doctor’s instructions. Avoid alcohol or certain medications that could influence results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy