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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess overall health and detect conditions like malnutrition or kidney disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41175-1
Short code
WEEV Ab Titr Fld
Synonyms
WEEV Ab Titr Fld
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order this test to check for signs of kidney disease, liver problems, malnutrition, dehydration, or certain infections. It can also help monitor long-term conditions like chronic kidney disease or heart failure.

What Does a Low or High Protein Level Mean?

Low protein levels might indicate poor nutrition, kidney problems, or severe infections. High protein levels could suggest dehydration, liver disease, or certain inflammatory conditions.

How Is the Test Performed?

A small blood sample is taken from a vein in your arm. The blood is then sent to a lab where it is analyzed to measure the total protein content.

What Are Common Results and Their Implications?

While specific reference ranges vary by lab, abnormal results often prompt further testing to identify underlying causes, such as specific protein fractions or organ function tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels are important for maintaining fluid balance, supporting immune function, and transporting nutrients. Abnormalities can signal systemic health issues requiring medical evaluation.

Short name

Total Protein

Frequently asked questions

Why might my doctor want to check my total protein level again?
Your doctor may repeat this test if you have symptoms like unexplained weight changes, fatigue, swelling, or if they suspect ongoing conditions like kidney disease or liver problems.
What can I do to prepare for this blood test?
No special preparation is needed, but avoid heavy meals before the test. If you’re on certain medications, let your healthcare provider know.
Could my diet affect my total protein test results?
Yes, diet can influence protein levels. Eating a balanced diet with adequate protein may help maintain stable results, but your doctor will focus on overall health rather than diet alone.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy