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Total Protein with Albumin/Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the balance between protein components in your blood, which can help assess liver function, kidney health, and overall protein status.

Quick summary

["Your blood protein balance may signal issues like liver disease, kidney problems, or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107657-9
Short code
Wheat Bran IgG Qn IA
Synonyms
Wheat Bran IgG Qn IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Protein in blood is made up of albumin and globulins. Albumin helps maintain fluid balance and carries other substances, while globulins support immune function. A ratio shift may indicate problems with production (e.g., liver disease) or breakdown (e.g., kidney issues).

What to Expect Before the Test

No special preparation is needed. You may eat and drink normally. If you’re on certain medications, let your provider know. Avoid alcohol 24 hours before testing to ensure accurate results.

Common Conditions Monitored

This test helps diagnose or track conditions like chronic liver disease, kidney disease, malnutrition, or inflammatory disorders. It can also guide decisions about fluid management or protein supplements.

What the Results Mean

Results show the proportion of albumin to globulin. A higher globulin ratio might suggest inflammation or immune disorders, while a lower ratio could point to liver or kidney problems. Your provider will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein Ratio

Frequently asked questions

How often do I need this test?
Your provider will determine frequency based on your health history and symptoms. Some patients with chronic conditions may need it yearly or more often, while others may only need it occasionally.
What causes abnormal results?
Abnormal ratios can result from liver disease (reduced albumin), kidney disease (increased globulins), infections, or inflammatory conditions. Other factors like dehydration, malnutrition, or certain medications may also affect results.
Can I adjust my diet before this test?
Avoid extreme dietary changes (e.g., very high or low protein intake) before testing. Stick to your usual diet unless instructed otherwise by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy