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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess your body’s protein balance and overall health of your liver and kidneys."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6737-1
Short code
Wheat IgG Qn
Synonyms
Wheat IgG Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, malnutrition, or certain infections. It can also help monitor long-term conditions like chronic kidney disease or liver disorders.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before the blood draw if your doctor specifies it. Bring any medications you’re currently taking.

What Happens During the Test?

A healthcare provider will draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort afterward.

What Are Possible Results?

Results are compared to standard ranges, but exact values can vary by lab. Low or high levels may signal underlying health concerns that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low total protein levels may indicate malnutrition, liver disease, kidney problems, or conditions like severe infections or inflammatory diseases. High levels can sometimes suggest dehydration, multiple myeloma, or certain liver disorders. Monitoring protein levels helps guide treatment decisions for chronic conditions.

Short name

Total Protein

Frequently asked questions

What does a low total protein level mean?
A low total protein level might suggest problems with your liver, kidneys, or nutrition. Your doctor could recommend further tests or adjustments to your diet or treatment plan.
What does a high total protein level mean?
High protein levels can sometimes point to conditions like dehydration, certain cancers (like multiple myeloma), or liver issues. Your doctor will discuss results with you to determine the next steps.
Does diet affect total protein test results?
Yes, diet can influence protein levels. Eating a balanced diet rich in proteins may help maintain normal levels, but your doctor will consider other factors when interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy