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Serum or Plasma Total Protein by Bromocresol Green (BCG) Method

Published: August 9, 2026Updated: August 17, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential nutritional or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
103080-8
Short code
Wheat (rTri a) 14 IgE RAST
Synonyms
Wheat (rTri a) 14 IgE RAST
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rast
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting protein levels, such as malnutrition, liver disease, kidney problems, or certain infections. It can also help monitor treatments for conditions like kidney disease or protein-losing disorders.

What Does a Low or High Total Protein Level Mean?

Low protein levels might indicate poor nutrition, severe liver disease, or kidney problems where proteins are lost in urine. High levels could suggest dehydration, inflammation, or conditions like multiple myeloma or severe infections.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to measure the total protein content using a specialized chemical method (bromocresol green).

What Are Common Causes of Abnormal Results?

Changes in total protein can result from dietary issues, chronic diseases (like cirrhosis or kidney disease), infections, or certain medications. It’s important to discuss your symptoms and medical history with your provider.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What does a normal range mean for this test?
There is no single ‘normal’ range provided here because reference intervals can vary by lab, age, and health status. Your results will be interpreted by your healthcare provider in the context of your overall health.
How often should I get this test?
Your provider will determine how often you need this test based on your medical condition, symptoms, and treatment plan. Regular monitoring may be needed if you have chronic health issues like kidney or liver disease.
Can diet or medications affect this test result?
Yes, diet (especially protein intake), certain medications (like steroids or diuretics), and medical conditions can influence protein levels. Always inform your provider about any medications or dietary changes before or after the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy