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Serum or plasma mass concentration of bilirubin (total)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin, a yellow pigment produced when red blood cells break down. It helps assess liver function and bile flow.

Quick summary

["Your liver’s ability to process bilirubin and prevent jaundice may be checked with this test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56422-9
Short code
White Birch IgG4-mCnc
Synonyms
White Birch IgG4-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total bilirubin test to diagnose or monitor conditions affecting the liver, bile ducts, or red blood cells. Common reasons include jaundice (yellowing of skin/eyes), unexplained fatigue, or symptoms like dark urine or pale stools.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a different method. Bring any medications or supplements you’re taking to your appointment.

How the Test Works

A healthcare provider will draw blood from a vein in your arm. The sample is sent to a lab, where bilirubin levels are measured using a specialized technique (often automated chemistry or spectrophotometry).

What the Results Mean

Results are typically reported in milligrams per deciliter (mg/dL). High levels may indicate liver disease, blockages in bile ducts, or hemolytic anemia (red blood cell breakdown). Low levels are less common but may signal liver dysfunction or certain genetic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total bilirubin

Frequently asked questions

What causes elevated bilirubin?
Elevated bilirubin can stem from liver diseases (e.g., hepatitis, cirrhosis), bile duct obstructions (e.g., gallstones), or conditions causing excessive red blood cell destruction (e.g., anemia). Always discuss symptoms with your doctor.
How often should I get this test?
Frequency depends on your health. Routine checks may be recommended if you have liver-related conditions, but your doctor will tailor follow-up based on your diagnosis and symptoms.
Can diet affect bilirubin levels?
Dietary factors like fiber, vitamin K, or certain medications (e.g., antibiotics) may indirectly influence liver function, but they don’t directly alter bilirubin levels. Avoid alcohol before testing if advised.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy