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Total Protein with Albumin/GLOBulin Separation (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein and breaks it down into albumin and globulin fractions, which help assess liver function, kidney health, and immune status.

Quick summary

["Helps diagnose conditions affecting protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
7622-4
Short code
White Poplar BasoBnd Ab Qn
Synonyms
White Poplar BasoBnd Ab Qn
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lhr
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Your body produces proteins like albumin and globulins to support vital functions, such as maintaining fluid balance, fighting infections, and transporting nutrients. Abnormal levels can signal underlying issues like liver disease, kidney problems, or chronic inflammation.

What to Expect During the Test

A simple blood draw from a vein in your arm is all it takes. The sample is sent to a lab for separation into albumin and globulin fractions, often using electrophoresis or similar methods. Results are reported as total protein and individual fractions.

Common Conditions This Test Helps Identify

High total protein or globulin levels might suggest conditions like multiple myeloma, chronic infections, or severe dehydration. Low albumin levels could indicate liver disease, malnutrition, or kidney failure.

How Your Results Are Interpreted

Results are compared to general reference ranges, but your doctor will consider your overall health, symptoms, and other test results to determine if any action is needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Imbalances Can Signal Serious Health Issues

Short name

Total Protein Profile

Frequently asked questions

What does a high or low total protein level mean?
High total protein may indicate conditions like multiple myeloma, severe dehydration, or chronic infections. Low total protein could signal liver disease, kidney problems, or malnutrition. Your doctor will review these results alongside other factors to guide next steps.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and other medical conditions. Regular monitoring may be recommended if you have liver, kidney, or immune-related illnesses.
Can diet or lifestyle affect protein test results?
Dietary changes may influence protein levels temporarily, but your doctor will account for this when interpreting results. Avoiding extreme diets or supplements before testing can help ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy