Serum/plasma substance concentration by immunoassay (tetramethylbenzidine-based) for a protein marker related to pruritus (itching)
This test measures a specific protein linked to itching, which may help assess underlying causes of persistent or unexplained skin itching.
["This test helps identify protein levels tied to itching, guiding treatment decisions if other causes aren’t clear."]
Key facts at a glance
- LOINC
- 24797-3
- Short code
- XR Abd AP+Obl Prone
- Synonyms
- XR Abd AP+Obl Prone
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- xr
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects the concentration of a protein associated with itching in your blood. It’s measured using a sensitive immunoassay method that reacts with a chemical called tetramethylbenzidine (TMB). This protein may be elevated in conditions causing chronic or unexplained itching.
Why It’s Ordered
Your healthcare provider may order this test if you have persistent itching that doesn’t respond to usual treatments. It could help rule out conditions like certain liver diseases, kidney disorders, or metabolic imbalances that may trigger itching.
Sample Collection
A blood sample is drawn from a vein in your arm. The blood is processed to separate the serum or plasma, which is then tested in a lab.
Preparation for the Test
No special preparation is needed. You may eat and drink normally before the test, but inform your provider if you’re on any medications that could affect blood results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated levels of this protein may indicate conditions such as chronic kidney disease, liver dysfunction, or certain autoimmune disorders. Lower-than-expected levels might suggest deficiencies or metabolic issues. This test is often used alongside other diagnostic tests to pinpoint the root cause of itching.
Short name
Pruritus-related protein level (serum/plasma)
Frequently asked questions
Will this test show if I have liver disease?
How long will I need to wait for results?
Can I take my usual medications before the blood draw?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy