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Alpha-1 Antitrypsin (Serum) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced mainly in the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin levels help identify potential lung or liver conditions linked to genetic mutations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36591-6
Short code
XR Abd Lat
Synonyms
XR Abd Lat
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have a family history of lung diseases like emphysema or chronic bronchitis, or if you have symptoms such as persistent coughing, shortness of breath, or unexplained liver issues. It can also be checked in people with certain genetic conditions affecting protein production.

What to Expect During the Test

A small blood sample will be taken from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The blood is then sent to a lab for analysis.

Preparation for the Test

No special preparation is needed for this test. However, if you’re taking certain medications or have recent infections, let your doctor know before the test.

Results and Next Steps

Results may take several days to a week, depending on lab processing times. Your doctor will discuss the findings with you and explain what they mean in the context of your health. Low levels may prompt further genetic testing or monitoring.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin (A1AT)

Frequently asked questions

What does an abnormal result mean?
An abnormal result could mean you have a genetic mutation affecting your Alpha-1 Antitrypsin levels. This may increase your risk for lung diseases or liver problems. Your doctor will discuss further steps, such as genetic counseling or lifestyle adjustments.
How often should I get this test?
If your doctor orders this test due to a family history or symptoms, they will determine how often you need follow-up testing. Regular monitoring may be recommended if you have a known genetic condition related to Alpha-1 Antitrypsin.
Can diet or exercise affect my Alpha-1 Antitrypsin levels?
While diet and exercise generally don’t directly alter Alpha-1 Antitrypsin levels, maintaining a healthy lifestyle can support overall lung and liver health, which may indirectly benefit your condition if you have an underlying genetic predisposition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy