Serum or Plasma Electrophoresis (Qualitative) with Bromocresol Purple Staining

What This Test Measures

Electrophoresis separates blood proteins based on size and charge using an electric field. Bromocresol purple dye binds to proteins, creating distinct bands that reflect protein types (e.g., albumin, globulins, alpha/beta/gamma fractions). Qualitative results indicate relative abundance rather than precise amounts.

Why It’s Ordered

Your doctor may order this test if you have symptoms like unexplained weight loss, bone pain, frequent infections, or abnormal lab results (e.g., high calcium or kidney function issues). It’s also used to monitor treatment responses in conditions like multiple myeloma.

Common Conditions Monitored

Abnormal patterns may suggest conditions like monoclonal gammopathy (e.g., multiple myeloma), Waldenström macroglobulinemia, or benign protein abnormalities. The test helps distinguish between normal and pathological protein distributions.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in the arm. The sample is processed to separate serum or plasma, then analyzed in a lab. Results are qualitative (descriptive bands) rather than numerical.