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Extracellular Matrix Remodeling Markers (General) – Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins or substances involved in breaking down and rebuilding tissues outside your cells, often checked in blood to assess conditions like fibrosis, inflammation, or tissue damage.

Quick summary

["This test helps doctors understand how your body’s tissues are changing over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42153-7
Short code
XR Extr 1V
Synonyms
XR Extr 1V
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test evaluates components of extracellular matrix remodeling, which includes proteins like collagenases, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs). These proteins play roles in tissue repair, wound healing, and disease progression (e.g., fibrosis, cancer metastasis).

Why It Might Be Ordered

Your doctor may recommend this test if you have symptoms or conditions linked to tissue remodeling, such as chronic lung disease, liver fibrosis, or certain cancers. It can also help monitor treatment responses in these cases.

Common Conditions Monitored

This test is sometimes used to track conditions where tissue breakdown or repair is abnormal, such as idiopathic pulmonary fibrosis, cirrhosis, or certain types of arthritis.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is processed to separate serum or plasma, which is then analyzed for specific remodeling markers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated levels of these markers may indicate ongoing tissue damage or remodeling, guiding treatment decisions for conditions like fibrosis or cancer. However, results alone don’t diagnose a specific condition; they’re interpreted alongside clinical findings and symptoms.

Frequently asked questions

What does a high or low result mean?
A high result may suggest active tissue remodeling, which could signal conditions like fibrosis or inflammation. A low result might mean less tissue breakdown or repair activity, but this isn’t definitive without clinical context.
How often will I need this test?
Your doctor will determine the frequency based on your health status, treatment plan, and symptoms. Some patients need it monthly, while others may only need it once.
Can I prepare for this test?
No special preparation is usually needed, but avoid heavy meals or strenuous activity before your blood draw. Follow your doctor’s instructions if you’re on certain medications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy