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Serum Creatinine (Creatinine Level)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood serum. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function by evaluating how well your kidneys remove waste from your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36565-0
Short code
XR Humerus 1V
Synonyms
XR Humerus 1V
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle breakdown and is naturally filtered out by your kidneys. High levels may indicate reduced kidney function, while low levels could suggest muscle underuse or overhydration. This test is often used alongside other measures to monitor kidney health, especially in people with risk factors like diabetes, high blood pressure, or a family history of kidney disease.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into a vein in your arm to draw blood. If you’re on a low-protein diet or have recently exercised, your doctor may advise timing your test to avoid potential fluctuations in creatinine levels.

Common Causes of Abnormal Results

High creatinine levels may signal impaired kidney function, dehydration, or conditions like heart failure or severe muscle damage. Low levels might suggest dehydration, overhydration, or conditions affecting muscle mass (e.g., malnutrition). Always discuss your results with your healthcare provider, as they’ll consider your full medical history and other test results.

When You Might Need This Test

Your doctor may order this test to evaluate kidney function before surgeries, check for kidney disease, monitor chronic conditions like diabetes or heart disease, or assess symptoms like fatigue, swelling, or changes in urine output.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Creatinine

Frequently asked questions

What symptoms might indicate I should get this test?
Symptoms like frequent urination, swelling in your legs or ankles, unexplained fatigue, or changes in urine color could signal kidney issues. Your doctor may also recommend this test if you have risk factors like high blood pressure, diabetes, or a family history of kidney disease.
How often should I get this test?
The frequency depends on your health. People with kidney disease or risk factors may need tests every few months, while others might only need it once or twice a year. Follow your doctor’s guidance.
Can diet or exercise affect my creatinine levels?
Yes, diet (especially protein intake) and exercise can influence creatinine levels. High protein diets may temporarily raise levels, while muscle loss (e.g., from illness) could lower them. Your doctor may adjust timing or instructions based on your lifestyle.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy