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Serum or plasma concentration of reactive lysine-derived cross-linked fibrin degradation products (D-dimer)

Published: August 9, 2026Updated: August 16, 2026

This test measures a breakdown product of blood clots, helping doctors assess whether you’re at risk of blood clots or bleeding problems.

Quick summary

["D-dimer helps guide decisions about blood thinners or further testing for clotting disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26114-9
Short code
XR LE-R Views
Synonyms
XR LE-R Views
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-dimer Used For?

D-dimer is primarily used to evaluate conditions involving abnormal blood clotting. It may be ordered to check for deep vein thrombosis (blood clots in veins), pulmonary embolism (clots in the lungs), or other clotting disorders. It can also help rule out bleeding disorders in certain situations.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum or plasma, where the D-dimer levels are measured using a sensitive lab test.

What Does a High or Low Result Mean?

High levels of D-dimer often suggest recent blood clotting activity, which can indicate conditions like thrombosis. Very low levels are generally normal and don’t indicate bleeding unless other symptoms are present.

Common Conditions Monitored

Doctors may use D-dimer results to diagnose or monitor conditions such as venous thromboembolism (clots in veins), arterial clots, or to assess bleeding risks in patients on anticoagulant medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-dimer

Frequently asked questions

Why might my doctor order a D-dimer test?
Your doctor may order this test if you have symptoms like leg swelling, chest pain, shortness of breath, or if you’ve been diagnosed with a clotting disorder. It can also be used to monitor treatment progress or rule out bleeding risks.
What are the typical reference ranges?
Reference ranges vary by lab and testing method. Generally, low levels are normal, while very high levels may indicate clotting activity. Your specific range will be provided with your results.
Can D-dimer test results be affected by medications?
Yes, certain medications like blood thinners (e.g., warfarin, heparin) or antiplatelet drugs can influence D-dimer levels. Always discuss your medications with your healthcare provider before or after the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy