Spinal Fluid Protein Profile (Electrophoresis)

What Does This Test Measure?

The spinal fluid protein profile uses electrophoresis to separate proteins into different categories, such as albumin, globulins, and other proteins. This separation helps doctors assess the balance of proteins in your spinal fluid, which can reveal clues about inflammation, immune responses, or structural changes in the nervous system.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like numbness, weakness, vision changes, or headaches that suggest a neurological issue. It’s also used to monitor conditions like multiple sclerosis, meningitis, or brain tumors by checking for abnormal protein levels or patterns.

How Is the Test Performed?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then sent to a lab for electrophoresis, where proteins are separated based on size and charge. Results are compared to expected patterns for your age and health status.

What Are Common Findings?

Normal results show balanced protein levels with typical patterns. Abnormal findings may include elevated protein levels (especially globulins), which could indicate inflammation, infections, or demyelination. Low albumin might suggest leakage from blood vessels or certain neurological disorders.