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Serum/Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle breakdown, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function by measuring how well your kidneys remove waste from your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36747-4
Short code
XR Mandible Views Obl
Synonyms
XR Mandible Views Obl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine levels can indicate how efficiently your kidneys filter blood. High levels may suggest kidney problems, while low levels could indicate dehydration or muscle disorders. This test is often used alongside other kidney function tests to diagnose conditions like chronic kidney disease.

What to Expect Before the Test

You may be asked to fast for 8–12 hours before the test, but this depends on your doctor’s instructions. Bring any medications you’re taking, as some may affect results. Avoid strenuous activity or excessive fluid intake on the day of testing.

How the Test Is Performed

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis using standard methods to measure creatinine concentration.

Possible Results and Interpretation

Results are compared to reference ranges, but exact values can vary by lab. High creatinine levels may signal kidney issues, while very low levels may require further investigation for causes like dehydration or muscle atrophy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine is a reliable marker for kidney function because it’s produced consistently by muscle metabolism and filtered by the kidneys. Elevated levels often prompt further evaluation for chronic kidney disease, acute kidney injury, or other conditions affecting kidney function. Low levels may raise concerns about dehydration, malnutrition, or muscle disorders, though they’re less common.

Short name

Creatinine

Frequently asked questions

How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and kidney function. Regular monitoring may be recommended if you have diabetes, high blood pressure, or a history of kidney problems.
What can affect my creatinine levels?
Several factors can influence creatinine levels, including dehydration, muscle mass, diet (especially protein intake), and certain medications. If you’ve had recent surgery, trauma, or changes in activity level, let your doctor know—these can temporarily alter results.
Do I need to prepare differently if I’m pregnant?
Yes, pregnant women may need adjusted timing or additional tests. Your doctor will provide specific instructions tailored to your situation, as creatinine levels can vary during pregnancy due to changes in kidney function and fluid balance.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy