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Serum or Plasma Total Protein with Albumin and Globulin Separation (Bromocresol Green Electrophoresis)

Published: August 9, 2026Updated: August 17, 2026

This test measures the different types of proteins in your blood, including albumin and globulin, to help diagnose conditions affecting protein levels or protein balance in your body.

Quick summary

["Understanding your protein breakdown helps identify potential health issues like liver disease, kidney problems, or infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
26140-4
Short code
XR Mastoid-L Views
Synonyms
XR Mastoid-L Views
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for conditions that affect how proteins are made, broken down, or used in your body. It can help diagnose or monitor diseases like multiple myeloma, liver disease, kidney disease, or certain types of infections.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw, where a small amount of blood is taken from a vein in your arm. If a urine sample is involved, you might be asked to collect a sample at home or in a lab setting.

What the Results Mean

The test separates proteins into different fractions (albumin, alpha, beta, and gamma globulins) using electrophoresis. Abnormal patterns may indicate conditions like protein loss, overproduction of certain proteins, or immune system disorders.

Common Conditions Monitored

This test helps track conditions such as chronic kidney disease, liver disease, inflammatory diseases (e.g., rheumatoid arthritis), or cancers like multiple myeloma, where protein levels can change.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein electrophoresis can signal underlying health issues by revealing imbalances in protein types. For example, high gamma globulins may suggest an immune disorder, while low albumin could indicate liver or kidney problems. Your provider will interpret results in the context of your symptoms and medical history.

Short name

Protein Electrophoresis (BCG Electrophoresis)

Frequently asked questions

What does a high or low protein level mean in this test?
High levels of certain proteins (like gamma globulins) may indicate chronic inflammation, infections, or autoimmune diseases. Low albumin levels often point to liver disease, kidney failure, or malnutrition. Your results will be reviewed by a healthcare provider to determine the next steps.
Can diet affect this test?
Dietary changes may influence protein levels indirectly, especially if you have kidney or liver issues. However, no specific diet restrictions are required for this test itself. Always follow your provider’s advice regarding dietary adjustments if you have known health conditions.
How often should I get this test?
Frequency depends on your health condition and provider’s recommendations. Some people need this test yearly or more often if they have ongoing diseases like kidney disease or cancer. Regular monitoring helps track changes in protein levels over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy