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Mast cell tryptase (serum/plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of tryptase, a protein released by mast cells, which are immune cells involved in allergic reactions and inflammation.

Quick summary

["Tryptase helps diagnose conditions linked to mast cell activation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
24830-2
Short code
XR Mastoid Views
Synonyms
XR Mastoid Views
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions where mast cells release too much tryptase, such as mastocytosis (a rare disorder where too many mast cells build up) or severe allergic reactions like anaphylaxis. It can also help monitor treatment progress or rule out other conditions causing similar symptoms.

What to Expect Before the Test

No special preparation is needed. You may have blood drawn from a vein in your arm. If you’re taking medications that affect blood clotting, let your doctor know beforehand.

What the Results Mean

Results can vary based on the test’s purpose. Elevated levels may suggest mast cell activation, while normal levels help rule out conditions like mastocytosis. Your doctor will interpret results in the context of your symptoms and medical history.

Common Conditions Monitored

This test is often used to diagnose or monitor mastocytosis, hereditary angioedema, or severe allergic reactions. It may also help assess conditions like urticaria (hives) or other immune-related disorders.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mast Cell Tryptase

Frequently asked questions

What causes elevated tryptase levels?
Elevated tryptase levels can occur due to mast cell activation from allergies, infections, trauma, or certain medications. In mastocytosis, levels may remain high even without triggers.
How often should I get this test?
Your doctor will determine frequency based on your condition. For example, patients with mastocytosis may need regular monitoring, while others may only need it if symptoms flare up.
Can diet or lifestyle affect tryptase levels?
Diet or lifestyle factors rarely directly impact tryptase levels, but managing triggers (e.g., allergens) may help prevent mast cell activation that could temporarily raise levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy