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Serum Creatinine (Creatinine Level)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test checks kidney function by measuring waste in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
103397-6
Short code
XR Neck 1V
Synonyms
XR Neck 1V
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
22
Ref high
198
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
CPT
82553
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle breakdown and is normally filtered out of your blood by your kidneys. High levels can indicate kidney problems, while low levels may suggest dehydration or muscle loss. This test is often used alongside other measures to evaluate kidney health, especially if you have symptoms like swelling, fatigue, or changes in urine output.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood. If you’re on a low-protein diet or have recently exercised, let your healthcare provider know, as these factors can slightly affect results.

What the Results Mean

Results are compared to a reference range, which can vary slightly by lab. Higher-than-normal levels may signal kidney issues, while very low levels could point to conditions like severe dehydration or muscle wasting. Your doctor will interpret results in the context of your overall health.

Common Causes of Abnormal Results

High creatinine levels may be caused by kidney disease, dehydration, severe muscle injury, or conditions that reduce blood flow to the kidneys. Low levels might result from dehydration, low muscle mass, or certain medications. Other factors, like pregnancy or liver disease, can also influence results.

Reference range

Adult males: 22-198 U/L; Females: 22-198 U/LN/A

Specimen: serum

No special preparation required. Inform provider of any chest pain or symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Creatinine

Frequently asked questions

Is creatinine testing part of a routine checkup?
Not always. Creatinine is often included in a broader kidney function panel (e.g., creatinine and blood urea nitrogen, or BUN) when kidney health is a concern, but your doctor may order it specifically if you have symptoms or risk factors like diabetes, high blood pressure, or a family history of kidney disease.
Can diet affect creatinine levels?
Yes. High-protein diets can temporarily raise creatinine levels, while very low-protein diets may lower them. However, diet alone doesn’t determine kidney function—your doctor will assess the bigger picture, including other health factors.
What if my creatinine level is high?
If your levels are elevated, your doctor may recommend further tests (like urine tests or imaging) to check kidney function. They could also adjust medications, monitor your diet, or treat underlying conditions like dehydration or heart disease to help manage levels.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy