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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in blood and evaluates the balance between albumin and globulin proteins, which can help assess overall protein status and immune function.

Quick summary

["Understanding your protein balance helps identify potential nutritional or immune system concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43570-1
Short code
XR port Hand Views
Synonyms
XR port Hand Views
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-portable
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This panel measures specific substances in your blood, such as nutrients, hormones, proteins, or waste products, to show how well your organs are working and whether any levels are too high or too low.

Total protein includes all proteins in your blood, primarily albumin and globulins. Albumin is a key carrier protein that helps maintain fluid balance, while globulins support immune function and other bodily processes. The ratio compares these two components to detect imbalances.

This test is done to help diagnose a health problem, monitor a condition you already have, or check how well a treatment is working. It may also be part of a routine checkup or used to look into symptoms such as fatigue, weakness, or unexplained changes in your health.

Your doctor may order this test to check for conditions like malnutrition, liver disease, kidney problems, or immune disorders. It can also help monitor chronic conditions like heart failure or infections.

A blood sample is usually drawn from a vein in your arm. A trained professional cleans the site, inserts a small needle, and fills one or more tubes, which takes only a few minutes. Some tests use urine, saliva, or a swab instead, and your care team will explain exactly what is needed.

A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis.

Your results are compared with a reference range, which shows the levels typically seen in healthy people. A result within range is usually reassuring, while a high or low value may point to a condition that needs follow-up. Your provider will review the numbers with you and explain what they mean for your situation.

Results may show elevated or low protein levels, or an abnormal albumin-to-globulin ratio. These findings can signal underlying health issues that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Profile

Frequently asked questions

How long will it take to get my results?
Do I need to fast before this test, or can I eat and drink normally ahead of time?
No special preparation is needed, but avoid alcohol for 24 hours before testing to ensure accurate results.
What should I do if my results come back out of range, and will I need repeat testing, further evaluation, or a treatment plan?
If results are abnormal, your doctor may recommend additional tests or treatments. Common follow-ups include dietary assessments, liver/kidney function tests, or immune evaluations.
The blood draw may cause mild discomfort, but it’s usually over quickly. Most people tolerate it well. Ask your healthcare provider if you have concerns.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy