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Alpha-1 Antitrypsin (A1AT) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["A1AT helps prevent lung disease and supports liver health by regulating enzymes that break down tissues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39064-1
Short code
XR Ribs Ant+Lat
Synonyms
XR Ribs Ant+Lat
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic cough, shortness of breath, or liver issues, or if you have a family history of conditions like alpha-1 antitrypsin deficiency. It’s also used to monitor lung or liver disease progression.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm, similar to other routine blood tests. You can eat and drink normally before the test.

What the Results Mean

Lower than expected levels of Alpha-1 Antitrypsin may indicate a genetic deficiency that increases your risk for lung diseases (like emphysema) or liver problems. Higher levels might be seen in certain liver diseases or during pregnancy.

Common Reasons for Testing

This test is often part of a broader evaluation for conditions like chronic obstructive pulmonary disease (COPD), liver cirrhosis, or hereditary lung diseases. It helps doctors diagnose and manage these conditions early.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

A1AT Serum

Frequently asked questions

What are the normal reference ranges for this test?
Reference ranges can vary by lab and may not be available publicly. Your healthcare provider will interpret your results in the context of your overall health and medical history. Very low levels of Alpha-1 Antitrypsin are particularly concerning for lung disease risk.
How often should I get this test?
If you have a known alpha-1 antitrypsin deficiency, your doctor may recommend regular monitoring. Otherwise, this test is usually ordered as needed for specific symptoms or risk factors.
Can lifestyle changes affect my A1AT levels?
While lifestyle factors like smoking can increase your risk of lung disease, they do not directly alter your A1AT blood levels. However, managing conditions like liver disease or respiratory infections may impact overall health outcomes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy