Serum or plasma concentration of ribonucleotide reductase large subunit (RRM1)
This test measures the level of the RRM1 protein, which plays a key role in DNA synthesis by converting ribonucleotides into deoxyribonucleotides. It may be used in research or specialized clinical contexts.
["RRM1 levels can help assess certain genetic or metabolic conditions, though it is not a standard diagnostic test for most health concerns."]
Key facts at a glance
- LOINC
- 39053-4
- Short code
- XR Ribs Lat
- Synonyms
- XR Ribs Lat
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- xr
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is RRM1 and Its Role in the Body?
Ribonucleotide reductase (RR) is an enzyme complex essential for cell division and DNA replication. The large subunit (RRM1) is a critical component that helps cells produce the building blocks needed for DNA repair and growth. Elevated or altered levels of RRM1 may be studied in research settings, particularly in oncology or genetic disorders.
Why Might Your Doctor Order This Test?
While RRM1 testing is not routinely performed for general health checks, it may be considered in specific research studies, clinical trials, or when investigating rare genetic conditions linked to DNA synthesis dysfunctions. Your healthcare provider would discuss its relevance to your situation.
How Is the Test Performed?
A blood sample is drawn, typically from a vein in your arm. The serum or plasma is then analyzed using a specialized laboratory technique, such as immunoassay or mass spectrometry, to measure RRM1 concentration.
What Do Results Mean?
Interpretation of RRM1 results depends on context, such as whether it’s part of a research study or a specialized diagnostic protocol. Normal ranges are not universally established for this test, as it is not a standard clinical marker.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
RRM1 is primarily studied in research contexts, including cancer biology (e.g., its role in tumor growth) and genetic disorders affecting DNA repair. Abnormal levels may indicate potential involvement in conditions like certain cancers or inherited metabolic diseases, but further evaluation would be required for diagnosis.
Short name
RRM1 (Ribonucleotide Reductase M1)
Frequently asked questions
Why would my doctor ask for this test?
How long will I need to wait for results?
Can I prepare for this test differently than other blood tests?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy