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Serum or Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps evaluate kidney function and detect early kidney damage."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
37867-9
Short code
XR Skull 2V
Synonyms
XR Skull 2V
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your kidneys normally filter waste products, including creatinine, from your blood. High levels of creatinine can signal impaired kidney function, while low levels may indicate dehydration or other conditions. This test is often used alongside other measures to monitor kidney health, especially in people with risk factors like diabetes, high blood pressure, or a family history of kidney disease.

What to Expect Before the Test

You may be asked to fast for a few hours before the test, but this is not always required. Drink plenty of water the day before if you suspect dehydration. Avoid strenuous exercise or certain medications that could affect kidney function, but always follow your healthcare provider’s specific instructions.

During the Test

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch or discomfort, but it usually takes only a few minutes. If you’re concerned about needles, let your provider know so they can offer alternatives.

What the Results Mean

Results are compared to a reference range, which can vary slightly by lab. High creatinine levels may indicate kidney problems, while very low levels might suggest dehydration or other conditions. Your doctor will interpret results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Creatinine

Frequently asked questions

How often should I get this test?
The frequency depends on your health status. People with kidney disease, diabetes, or high blood pressure may need this test more often, often every 3–6 months. If you have no known risk factors, your doctor may recommend it less frequently, such as once a year.
Can diet or hydration affect creatinine levels?
Yes. Drinking too little water can raise creatinine levels, while excessive fluid intake may lower them. Eating high-protein foods can also temporarily increase creatinine levels, but this effect is usually short-term. Always follow your doctor’s advice on diet and hydration before testing.
What if my results are outside the normal range?
If your results are high, your doctor may recommend further tests or treatments to manage kidney function, such as adjusting medications, improving diet, or monitoring other health conditions. If low, they may investigate causes like dehydration or other metabolic issues. Never interpret results alone—always discuss them with your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy