Serum or Plasma Total Protein with Albumin-to-Globulin Ratio (TGA)

Why This Test Matters

Total protein and albumin-globulin ratios are important because they reflect how well your body produces and maintains proteins. Albumin, a key protein made by your liver, helps keep fluids in your bloodstream and supports immune function. Globulins, also produced by the liver and immune system, include proteins like antibodies that fight infections. Abnormal ratios may indicate conditions such as malnutrition, liver disease, chronic inflammation, or kidney problems.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw from a vein in your arm, similar to other routine blood tests. If you’re on certain medications or have recent infections, let your provider know, as it may affect results.

What the Results Mean

A high albumin-to-globulin ratio often suggests healthy protein production, while a low ratio may point to conditions like liver disease, malnutrition, or chronic inflammation. Total protein levels alone don’t provide enough detail, so the albumin-globulin ratio helps narrow down possible causes.

Common Conditions Linked to Abnormal Results

Elevated ratios may be seen in conditions like chronic liver disease or certain infections. Low ratios could indicate liver dysfunction, malnutrition, or kidney disease. Your provider will discuss these findings in relation to your overall health and symptoms.